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Phage Therapy in Poultry

Antibiotic resistance is an increasingly common phenomenon in the poultry industry, and phage therapy is widely used to control disease-causing microorganisms present in poultry farms as an alternative therapy to control bacterial populations. In order to better manage poultry farming, reduce the risk of food poisoning in poultry and egg products and expand research on phage therapy, Creative Biolabs currently provides the most stable and advanced phage development services to clients around the world.

Introduction of Phage Therapy in Poultry

Bacteriophage is a virus that infects only bacteria. It has a narrow specificity and the ability to self-proliferate, which makes it a more potential pathogen control agent in the poultry industry instead of antibiotics. As a means of preventing, treating and combating avian infectious diseases caused by bacterial pathogens, the application of bacteriophages in poultry farming mainly includes controlling disease transmission in farms, reducing the transmission of zoonotic pathogens to humans through chicken meat, and meat preservation during production, processing and sale. According to the different life cycles, phages can be divided into virulent phages and temperate phage, among which virulent phages are more used for the sterilization and population control of specific bacterial species due to their ability to lyse host bacteria. The most common bacterial species in poultry farming include:


Salmonella is a rod-shaped gram-negative bacterium of the Enterobacteriaceae family, with several subspecies and thousands of serotypes. The main types of transmission in poultry farms are Salmonella enteritidis, Salmonella typhimurium, Salmonella infantis, etc. Non-typhoid Salmonella has become one of the main causes of food-borne zoonotic diseases, which can lead to enteritis and gastrointestinal diseases after ingesting food containing certain concentrations of bacteria. Phage therapy against Salmonella has been started as early as 1926. Hundreds of phages have been isolated from various medium components, and several of them have shown the ability to inhibit Salmonella colonies in experiments.

Percentage of Salmonella phages isolated from broilers and layers.Fig. 1 Percentage of Salmonella phages isolated from broilers and layers. (Sevilla, 2020)

Escherichia coli

Poultry colibacillosis caused by avian pathogenic E. coli causes severe respiratory infections and sepsis, as well as neuropathy such as meningitis when E. coli invades the nervous system, these diseases are often incurable and have a high mortality rate. The anti-colibacillosis ability of phages like SPR02, DAF6 and Phi F78E has been validated in various animal models.

Campylobacter jejuni

Campylobacter jejuni is a gram-negative, spiral-shaped bacterium that can co-occur in the gastrointestinal tract of many animals, especially birds and fowl. Infections caused by Campylobacter have been the leading cause of foodborne zoonotic diseases, requiring only very low doses to infect humans and cause gastroenteritis and cause debilitating. Although rarely life-threatening, it also poses a serious health threat. Phages such as CP220 and CP20 can effectively control the colony number of Campylobacter in animal models and in vitro experiments and slow down the loss after infection in poultry farms.

Density after co-culture of Campylobacter and phage.Fig. 2 Density after co-culture of Campylobacter and phage. (Sandhu, 2021)


As a leading company in the field of biotechnology, Creative Biolabs process an excellent and advanced phage-related technology platform and provides novel phage therapy in poultry development services to customers around the world, including phage isolation, purification, enrichment, identification, gene sequencing, and characterization. We also edit and modify phage according to your needs, quantify and characterize phage population control ability and phage resistance of pathogenic bacteria through different validation assays. In addition, we are happy to improve existing methods or develop new experimental programs for you according to your needs. Please do not hesitate to contact us for more information. You can also click the link below for further information:


  1. Sevilla, S.; et al. Salmonella bacteriophage diversity according to most prevalent Salmonella serovars in layer and broiler poultry farms from eastern Spain. Animals. 2020, 10: 1456.
  2. Sandhu, S.K.; et al. How does feedback from phage infections influence the evolution of phase variation in Campylobacter. PLoS Comput Biol. 2021, 17(6): e1009067.
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