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Phage Therapy in Pig

With the emergence of multidrug-resistant bacteria, the ability of antibiotics to control bacterial growth in agriculture and animal husbandry is also diminishing. However, bacteriophages have attracted extensive attention in the research community as a tool that can be used to combat bacterial diseases as a powerful means of preventing and treating bacterial diseases in animal husbandry. Creative Biolabs currently provide our customers around the world with the most advanced and comprehensive phage therapy development services for the improvement and safety of the swine farming industry.

Introduction of Phage Therapy in Pig

Bacteriophages are a class of viruses that infect bacteria with narrow specificity. They can complete self-proliferation in host cells and inhibit the reproduction of specific bacterial populations while having little or no effect on other bacterial populations in nature. The goals of phage therapy in the swine industry mainly include reducing the impact of infectious diseases caused by several typical bacterial pathogens on animal health and production, as well as reducing the number of bacteria transmitted to humans through pork products, processed foods and the pig itself to control the transmission of zoonotic diseases. Phage therapy against different pathogenic bacteria has also been researched and developed as a highly potential tool against bacterial diseases in pigs.

Escherichia coli

Escherichia coli is a facultative anaerobic Gram-negative bacterium. Infections with pathogenic strains of E. coli cause diarrhea, enteritis, uremia, or meningitis. E. coli pathogenic strains commonly found in the pig industry, including O20, O157, and O149, have been recognized as one of the most important zoonotic human pathogens, and many strains have developed multidrug resistance. Many phages have been isolated and evaluated against different strains, and the antibacterial ability of a series of phages against E. coli, such as P433/1, P433/2, and PP01, has been verified in the gastrointestinal ecosystem or in vitro models.

Effects of bacteriophages on E. coli from pig or turkey.Fig. 1 Effects of bacteriophages on E. coli from pig or turkey. (Skaradzinska, 2017)


Salmonella is one of the most common food- and water-borne pathogens causing severe diarrhea in humans, multiple serotypes have been isolated from various stages of swine production. In fact, with the increasing incidence of Salmonella infections, it is a serious threat to food safety and meat production in the pig industry. Dozens of Salmonella phage genomes have been measured and reported, including Salmonella Enteritidis and Salmonella Typhimurium phages.

Other Bacteria

Yersinia enterocolitica, Bordetella bronchiseptica, Pasteurella multocida, etc. are all considered to cause various diseases in pigs and seriously threaten the pig industry. Several promising phage therapy options have been proposed, which can effectively control the population of target pathogens and reduce the risk of food poisoning and zoonotic diseases.

Services in Creative Biolabs

With our strong technology platform and cutting-edge theoretical knowledge, Creative Biolabs provides novel phage therapy in swine industry development services, including but not limited to the isolation, enrichment, purification, identification, gene sequencing, characterization, and engineering of various types of phage. In addition, we also quantify and characterize the parasitic and killing ability of phages against specific strains through various in vitro and in vivo validation assays.

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  1. Skaradzinska, A.; et al. The efficacy of isolated bacteriophages from pig farms against ESBL/AmpC-producing Escherichia coli from pig and turkey farms. Frontiers in Microbiology. 2017, 29(8): 530.
For Research Use Only. Do NOT use in humans.

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* For Research Use Only. We do not provide direct services or products for patients.