Phage and Salmonella

Creative Biolabs is one of the well-recognized experts who are professionals in phage for the development of phage-based therapy. Our scientists are proud to tailor the best-fit solutions for phage-related research and development to meet your specific project requirements to treat Salmonella infections. With over ten years of extensive experience and our advanced phage platforms, we are ready to provide you strong support for your projects.

Salmonella and Salmonellosis

Salmonella is a genus of rod-shaped Gram-negative facultative anaerobes, that belongs to the family of Enterobacteriaceae. Salmonella enterica and Salmonella bongori are two species belong to the genus of Salmonella. Salmonella is present in the intestinal tract of humans and animals. Salmonellosis is a zoonotic disease that can be transmitted through environmental, contact, and oral route. People can get infected with Salmonella through a variety of routes, including eating uncooked or contaminated food, drinking contaminated water, and coming in contact with infected animals, feces, or the environment. People who have recently taken antacids or antibiotics, people with inflammatory bowel disease (IBD), the elderly, young children, and immunocompromised groups have a lower defense to Salmonella and are more susceptible to Salmonella infection and develop salmonellosis. The clinical symptoms of salmonella affect the stomach and intestines, appearing diarrhea, abdominal pain and cramps, and fever. Severe Salmonella infections need to be treated with antibiotics. However, with the development of antibiotic resistance, there is a growing awareness of the importance of developing novel drugs.

Bacteriophages of Salmonella

Researchers have been interested in phages as an alternative to antibiotics because of their lytic effect on certain bacteria. Phages can be employed as a resource for bacterial isolation and diagnostics, as well as a therapeutic technique for treating hazardous Salmonella infections, since of their selectivity for bacteria, low manufacturing costs, and anti-resistance properties. Phages with a broad host range can be used to identify a variety of bacterial pathogens in food samples, and thus can be used to detect foodborne Salmonella. Phage cocktail therapy is an effective approach for targeting Salmonella species and subspecies infections by increasing the host range and targeting the full spectrum of Salmonella. Considering that Salmonella primarily infects the intestinal tract, the influence of the intestinal environment on phage activity, including temperature, pH, etc., needs to be taken into account in the development of its formulation and stability. Phage encapsulation in micro- and nanoparticles appears to be an effective formulation method for Salmonella phage.

Fig.1 Transmission electron microscopy images of four Salmonella phages. (Xie, 2021)

As a famous expert with high reputation in the phage field, Creative Biolabs devotes to offering global customers a full range of services in developing and manufacturing of phage-based therapy, phage-based vaccines, and phage-derived proteins. Our professionals with academic expertise are willing to give you support in your research and development process. If you are interested in phages and Salmonella, please don't hesitate to contact us.

Reference:

1. Xie, Y.; et al. Differential bacteriophage efficacy in controlling Salmonella in cattle hide and soil models. Frontiers in Microbiology. 2021, 12: 1733.